Hyris technology supports the fight against one of the world's deadliest diseases, malaria

Hyris' molecular diagnostics technology has been adapted to allow real-time monitoring of insecticide resistance in mosquito vectors, which will aid in malaria control campaigns.

LONDON, UK / ACCESSWIRE / 2024 February 20 / Hyris, in collaboration with an international team of researchers, has developed a prototype field-deployable surveillance system that allows the detection of insecticide-resistant malaria-carrying mosquitoes in the field without the need to transport them to complex laboratories. The prototype can diagnose mosquito resistance to insecticides in the field three hours or less after capture. Current methods can take up to six months, as samples must be collected in remote areas and transported to centralized laboratories for testing.

Hyris is fighting malaria
The vector of the disease is mosquitoes

Early and cost-effective detection of insecticide resistance in mosquitoes is essential for planning and implementing effective malaria control strategies. Mosquito-killing insecticides remain key weapons in preventing the spread of malaria in sub-Saharan Africa and other malaria-endemic parts of the world. However, mosquitoes often develop resistance to insecticides, making them ineffective at preventing the spread of disease.

The research group is headed by a professor George Dimopoulos at the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins Malaria Research Instituteand together with the professor Charles Wondji at the Infectious Disease Research Center in Yaounde, Cameroon the team has been working since 2021, conducting laboratory research and development and field trials in malaria-endemic areas of Cameroon. It is enabled by exclusive features Hyris system™ for molecular research that is based on a simple portable battery-powered device rather than a heavy laboratory benchtop machine.

The newly developed Hyris technology pre-filled dried cartridges allow a diagnostic test to be performed by simply placing a mosquito sample in a well that already contains all other reagents, thus simplifying the testing process. The stability of the dried reagents allows them to be stored at room temperature for up to six months, eliminating the need for refrigeration, which is lacking in many field sampling sites.

This research project was supported by a Bill and Melinda Gates Foundation scholarship to Johns Hopkins University.

“This new test can be applied in the field,” explains Lorenzo Colombo, CTO and CEO of Hyris. “Our technology allows researchers to sample mosquitoes in the field and perform molecular diagnostic testing. real-time data on insecticide resistance from the disease-endemic area is available from a central laboratory“.

The team is currently investigating the possibility of implementing a country-wide mosquito insecticide resistance monitoring system in Cameroon, which would allow real-time decisions to be made about malaria mosquito control campaigns using the most effective insecticides.

Stefano Lo Priore, Founder and CEO of HyrisThe benefits of this new test are explained below: “The need for a cold chain has always been a major obstacle to any rollout of the test in remote areas. This new test for resistance to an insecticide against malaria mosquitoes does not require any cold chain for transport, so it can be used in the field.” Lo Priore also emphasizes how such projects fit perfectly with Hyris' commitment developing advanced biotechnological solutions for critical environments. “We strive to provide increasingly effective ways to manage outbreak preparedness and health prevention, especially in the most challenging situations.”

For more information, contact a Hyris specialist at [email protected].

Contact information

Gabriele Salaris
Global Experience Guide
[email protected]
+39 345 555 3379

SOURCE: Hyris Ltd

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